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fastigial nucleus  (Addgene inc)


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    Addgene inc fastigial nucleus
    (A) Experimental design. AAV1-Cre was injected in the DCN of RCE:loxP mice to trace DCN-recipient cells in the SNc. (B) Representative image of cerebellum showing bilateral injection in the DCN. AAV1-Cre virus is visualized with GFP in green. DAPI staining is shown in blue. DN: dentate nucleus, IntN: interposed nucleus, FN: <t>fastigial</t> nucleus. Scale bar: 750 µm. Zoom in of the infected cells in the interposed nuclei. Scale bar: 100 µm. (C) (Left panel) Representative image of the SNc showing DCN-recipient cells (green). TH staining was performed to delimit the structure and to label for dopaminergic neurons (red). Scale bar: 100 µm. Zoom in of the SNc showing DCN-recipient cells. Arrows point TH-positive and arrowhead, TH-negative GFP cells. Scale bar: 50 µm. (Right panel) Examples of dopaminergic (left column) and non-dopaminergic (right column) DCN-recipient cells. Scale bars: 25 µm. (D) Distribution of individual DCN-recipient neurons along the antero-posterior (A-P) SNc. (Top left) Schematic of brain region analyzed. All DCN-recipient cells were mapped in representative bregma schematics from anterior to posterior SNc. Only right SNc is shown. Cells of N = 3 mice were mapped. Scale bar: 250 µm. SNr: substantia nigra reticulata. (E) Quantification of the number DCN-recipient cells in the SNc along the A-P axis (represented by bregma position). Mean ± SD, N= 3.
    Fastigial Nucleus, supplied by Addgene inc, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/fastigial nucleus/product/Addgene inc
    Average 93 stars, based on 1 article reviews
    fastigial nucleus - by Bioz Stars, 2026-05
    93/100 stars

    Images

    1) Product Images from "Cerebellum Directly Modulates the Substantia Nigra Dopaminergic Activity"

    Article Title: Cerebellum Directly Modulates the Substantia Nigra Dopaminergic Activity

    Journal: bioRxiv

    doi: 10.1101/2022.05.20.492532

    (A) Experimental design. AAV1-Cre was injected in the DCN of RCE:loxP mice to trace DCN-recipient cells in the SNc. (B) Representative image of cerebellum showing bilateral injection in the DCN. AAV1-Cre virus is visualized with GFP in green. DAPI staining is shown in blue. DN: dentate nucleus, IntN: interposed nucleus, FN: fastigial nucleus. Scale bar: 750 µm. Zoom in of the infected cells in the interposed nuclei. Scale bar: 100 µm. (C) (Left panel) Representative image of the SNc showing DCN-recipient cells (green). TH staining was performed to delimit the structure and to label for dopaminergic neurons (red). Scale bar: 100 µm. Zoom in of the SNc showing DCN-recipient cells. Arrows point TH-positive and arrowhead, TH-negative GFP cells. Scale bar: 50 µm. (Right panel) Examples of dopaminergic (left column) and non-dopaminergic (right column) DCN-recipient cells. Scale bars: 25 µm. (D) Distribution of individual DCN-recipient neurons along the antero-posterior (A-P) SNc. (Top left) Schematic of brain region analyzed. All DCN-recipient cells were mapped in representative bregma schematics from anterior to posterior SNc. Only right SNc is shown. Cells of N = 3 mice were mapped. Scale bar: 250 µm. SNr: substantia nigra reticulata. (E) Quantification of the number DCN-recipient cells in the SNc along the A-P axis (represented by bregma position). Mean ± SD, N= 3.
    Figure Legend Snippet: (A) Experimental design. AAV1-Cre was injected in the DCN of RCE:loxP mice to trace DCN-recipient cells in the SNc. (B) Representative image of cerebellum showing bilateral injection in the DCN. AAV1-Cre virus is visualized with GFP in green. DAPI staining is shown in blue. DN: dentate nucleus, IntN: interposed nucleus, FN: fastigial nucleus. Scale bar: 750 µm. Zoom in of the infected cells in the interposed nuclei. Scale bar: 100 µm. (C) (Left panel) Representative image of the SNc showing DCN-recipient cells (green). TH staining was performed to delimit the structure and to label for dopaminergic neurons (red). Scale bar: 100 µm. Zoom in of the SNc showing DCN-recipient cells. Arrows point TH-positive and arrowhead, TH-negative GFP cells. Scale bar: 50 µm. (Right panel) Examples of dopaminergic (left column) and non-dopaminergic (right column) DCN-recipient cells. Scale bars: 25 µm. (D) Distribution of individual DCN-recipient neurons along the antero-posterior (A-P) SNc. (Top left) Schematic of brain region analyzed. All DCN-recipient cells were mapped in representative bregma schematics from anterior to posterior SNc. Only right SNc is shown. Cells of N = 3 mice were mapped. Scale bar: 250 µm. SNr: substantia nigra reticulata. (E) Quantification of the number DCN-recipient cells in the SNc along the A-P axis (represented by bregma position). Mean ± SD, N= 3.

    Techniques Used: Injection, Staining, Infection



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    fastigial nucleus  (Addgene inc)
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    Addgene inc fastigial nucleus
    (A) Experimental design. AAV1-Cre was injected in the DCN of RCE:loxP mice to trace DCN-recipient cells in the SNc. (B) Representative image of cerebellum showing bilateral injection in the DCN. AAV1-Cre virus is visualized with GFP in green. DAPI staining is shown in blue. DN: dentate nucleus, IntN: interposed nucleus, FN: <t>fastigial</t> nucleus. Scale bar: 750 µm. Zoom in of the infected cells in the interposed nuclei. Scale bar: 100 µm. (C) (Left panel) Representative image of the SNc showing DCN-recipient cells (green). TH staining was performed to delimit the structure and to label for dopaminergic neurons (red). Scale bar: 100 µm. Zoom in of the SNc showing DCN-recipient cells. Arrows point TH-positive and arrowhead, TH-negative GFP cells. Scale bar: 50 µm. (Right panel) Examples of dopaminergic (left column) and non-dopaminergic (right column) DCN-recipient cells. Scale bars: 25 µm. (D) Distribution of individual DCN-recipient neurons along the antero-posterior (A-P) SNc. (Top left) Schematic of brain region analyzed. All DCN-recipient cells were mapped in representative bregma schematics from anterior to posterior SNc. Only right SNc is shown. Cells of N = 3 mice were mapped. Scale bar: 250 µm. SNr: substantia nigra reticulata. (E) Quantification of the number DCN-recipient cells in the SNc along the A-P axis (represented by bregma position). Mean ± SD, N= 3.
    Fastigial Nucleus, supplied by Addgene inc, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/fastigial nucleus/product/Addgene inc
    Average 93 stars, based on 1 article reviews
    fastigial nucleus - by Bioz Stars, 2026-05
    93/100 stars
    		  Buy from Supplier

    Image Search Results


    (A) Experimental design. AAV1-Cre was injected in the DCN of RCE:loxP mice to trace DCN-recipient cells in the SNc. (B) Representative image of cerebellum showing bilateral injection in the DCN. AAV1-Cre virus is visualized with GFP in green. DAPI staining is shown in blue. DN: dentate nucleus, IntN: interposed nucleus, FN: fastigial nucleus. Scale bar: 750 µm. Zoom in of the infected cells in the interposed nuclei. Scale bar: 100 µm. (C) (Left panel) Representative image of the SNc showing DCN-recipient cells (green). TH staining was performed to delimit the structure and to label for dopaminergic neurons (red). Scale bar: 100 µm. Zoom in of the SNc showing DCN-recipient cells. Arrows point TH-positive and arrowhead, TH-negative GFP cells. Scale bar: 50 µm. (Right panel) Examples of dopaminergic (left column) and non-dopaminergic (right column) DCN-recipient cells. Scale bars: 25 µm. (D) Distribution of individual DCN-recipient neurons along the antero-posterior (A-P) SNc. (Top left) Schematic of brain region analyzed. All DCN-recipient cells were mapped in representative bregma schematics from anterior to posterior SNc. Only right SNc is shown. Cells of N = 3 mice were mapped. Scale bar: 250 µm. SNr: substantia nigra reticulata. (E) Quantification of the number DCN-recipient cells in the SNc along the A-P axis (represented by bregma position). Mean ± SD, N= 3.

    Journal: bioRxiv

    Article Title: Cerebellum Directly Modulates the Substantia Nigra Dopaminergic Activity

    doi: 10.1101/2022.05.20.492532

    Figure Lengend Snippet: (A) Experimental design. AAV1-Cre was injected in the DCN of RCE:loxP mice to trace DCN-recipient cells in the SNc. (B) Representative image of cerebellum showing bilateral injection in the DCN. AAV1-Cre virus is visualized with GFP in green. DAPI staining is shown in blue. DN: dentate nucleus, IntN: interposed nucleus, FN: fastigial nucleus. Scale bar: 750 µm. Zoom in of the infected cells in the interposed nuclei. Scale bar: 100 µm. (C) (Left panel) Representative image of the SNc showing DCN-recipient cells (green). TH staining was performed to delimit the structure and to label for dopaminergic neurons (red). Scale bar: 100 µm. Zoom in of the SNc showing DCN-recipient cells. Arrows point TH-positive and arrowhead, TH-negative GFP cells. Scale bar: 50 µm. (Right panel) Examples of dopaminergic (left column) and non-dopaminergic (right column) DCN-recipient cells. Scale bars: 25 µm. (D) Distribution of individual DCN-recipient neurons along the antero-posterior (A-P) SNc. (Top left) Schematic of brain region analyzed. All DCN-recipient cells were mapped in representative bregma schematics from anterior to posterior SNc. Only right SNc is shown. Cells of N = 3 mice were mapped. Scale bar: 250 µm. SNr: substantia nigra reticulata. (E) Quantification of the number DCN-recipient cells in the SNc along the A-P axis (represented by bregma position). Mean ± SD, N= 3.

    Article Snippet: For dopamine measurements, AAV1.hSyn.ChR2 (H134R)-eYFP.WPRE.hGH (Addgene #26973P) was injected bilaterally at coordinates: -6.0 AP, ± 2.3 ML, -2.0 DV for Dentate nucleus, -6.24 AP, ± 1.5 ML, -2.0 DV for Interposed nucleus, and -6.37 AP, ± 0.8 ML, -2.0 DV for Fastigial nucleus (0.4 µl per injection site).

    Techniques: Injection, Staining, Infection